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ZHANG, HUIBIN

Time:2018-02-01   Browse times:358

Zhang Huibin, female, born in December 1964, graduated from Nanjing College of Pharmacy in 1984 with a bachelor degree in pharmaceutical chemistry. In 1989 and 2004, she obtained master and doctor degrees in medicinal chemistry from China Pharmaceutical University respectively. Since 1989, she has been engaged in the research and development of new drugs in the New Drug Research Center of China Pharmaceutical University. She is a director of the National Natural Science Foundation of China, the state major new drug creation special, joint research and innovation projects of Jiangsu Province. Dr. Zhang has completed 3 projects of Natural Science Foundation of Jiangsu Province. A dozens of postgraduate students has completed thire thesis under her supervision to get master and doctor degrees. In addition, she is an expert reviewer of the national natural science fund. Dr. Zhang has applied for more than 20 patents, obtained 9 authorized patents and published more than 90 papers.

  

Representative Publications:

1. Junhao Xing, Lingyun Yang, Yifei Yang, Leilei Zhao, Qiangqiang Wei, Jian Zhang,Jinpei Zhou, Huibin Zhang*. Design, synthesis and biological evaluation of novel 2,3-dihydroquinazolin-4(1H)-one derivatives as potential fXa inhibitors. European Journal of Medicinal Chemistry, 2017,125,411-422.

2. Leilei Zhao, Yifei Yang, Yahui Guo, Lingyun Yang, Jian Zhang, Jinpei Zhou*, Huibin Zhang*. Design, synthesis and biological evaluation of 7-methylimidazo [1,5-a]pyrazin-8 (7H)-one derivatives as BRD4 inhibitors. Bioorganic & Medicinal Chemistry, 2017, 25(8), 2482-2490.

3. Lingyun Yang, Li Han, Bin Xu, Leilei Zhao, Jinpei Zhou, and Huibin Zhang*. Palladium-Catalyzed C−HBondOrthoAcylation/AnnulationwithTolueneDerivatives Toluene Derivatives.Asian Journal of Organic Chemistry, 2016, 5 (1): 62-65 .

4. Xing J, Yang L, Li H, Li Q, Zhao L, Wang X, Zhang Y, Zhou M, Zhou J, Zhang H*. Identification of anthranilamide derivatives as potential factor Xa inhibitors: drug design, synthesis and biological evaluation. Eur J Med Chem, 2015 5; 95: 388-99

5. Li Q, Zhou M, Han L, Cao Q, Wang X, Zhao L, Zhou J, Zhang H*. Design, Synthesis and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel DPP-4 Inhibitors. Chem Biol Drug Des,  2015, 86(4): 849-56

6. Xing J, Li Q, Zhang S, Liu H, Zhao L, Cheng H, Zhang Y, Zhou J, Zhang H*. Identification of Dipeptidyl Peptidase IV Inhibitors: Virtual Screening, Synthesis and Biological Evaluation. Chem Biol Drug Des. 2014 , 84(3):364-77.

7. Li Q, Hu Q, Wang X, Zong Y, Zhao L, Xing J, Zhou J, Zhang H*. Discovery of Novel 2-(piperidin-4-yl)-1H-benzo[d]imidazole Derivatives as Potential Anti-Inflammatory Agents. Chem Biol Drug Des. 2015, 86(4):509-16.

8. Huibin Zhang, Yaan Zhang, Guanzhong Wu, Jinpei Zhou, Wenlong Huang, Xiaowen Hu, Synthesis and biological evaluation of sulfonylurea and thiourea derivatives substituted with benzenesulfonamide groups as potential hypoglycemic agents , Bioorganic & Medicinal Chemistry Letters, 2009, 19(6), 1740-1744

9. Jing Li, Huibin Zhang,*, Wenlong Huang, Hai Qian and Ying Li. TNF-Inhibitors with Anti-Oxidative Stress Activity from Natural Products. Current Topics in Medicinal Chemistry, 2012, 12, 1408-1421

10. Huibin Zhang, Yaan Zhang, Guanzhong Wu, Jinpei Zhou, Wenlong Huang, Xiaowen Hu, Synthesis and biological evaluation of sulfonylurea and thiourea derivatives substituted with benzenesulfonamide groups as potential hypoglycemic agents , Bioorganic & Medicinal Chemistry Letters, 2009, 19(6), 1740-1744

11. Yubin Wang, Hai Qian, Jinpei Zhou, Huibin Zhang*, and Jianfeng Ji and Wenlong Huang. Synthesis and Bioactivities of 2-Azetidinone Derivatives as Cholesterol Absorption Inhibitors. Medicinal Chemistry, 2011, 7, 534-542

12. Wenyuan Liu, Ainan Zhoua, Feng Feng, Huibin Zhang*, Jinpei Zhou, Wenlong Huang. Qualitative and quantitative studies on impurities in G004, a potential hypoglycaemic agent, using liquid chromatography, nuclear magnetic resonance and mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis, 2011, 56, 627-632

13. Hui Bin Zhang, Yu Shi Chi, Wen Long Huang, Shuai Jian Ni. Total synthesis of human urotension-II by microwave-assisted solid phase method. Chinese Chemical Letters, 2007, 18 : 902–904.

14. Yushi Chi, Huibin Zhang*, Wenlong Huang, Jinpei Zhou, Yinghong Zhou, Hai Qian, Shuaijian Ni. Microwave-assisted solid phase synthesis, PEGylation, and biological activity studies of glucagon-like peptide-1(7–36) amideBioorganic & Medicinal Chemistry, 2008, 16 (16),7607-7614

15. Chi, Yushi; Zhang, Huibin*; Zhou, Jinpei; Huang, Wenlong; Ni, Shuaijian, Microwave-Assisted Solid Phase Synthesis of GLP-1-Analogues, Letters in Organic Chemistry, 2008 5(5),399-402(4)

16. Yu Li, Hui-bin Zhang*, Wen-long Huang, Yun-man Li Design and synthesis of tetrahydroisoquinoline derivatives as potential multidrug resistance reversal agents in cancerBioorganic & Medicinal Chemistry Letters, 2008, 18(12),3652-3655

17. Jing Li, Wenlong Huang, Huibin Zhang*, Xinyang Wang, Huiping Zhou. Synthesis of andrographolide derivatives and their TNF-α and IL-6 expression inhibitory activitiesBioorganic & Medicinal Chemistry Letters, 2007,17(24) , 6891-689

  

Contact Information:

Email: zhanghb80@163.com


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