新利18体育,18新利体育网页登录入口,18新利

Current Location:homepage  informations  doctordoctor

​LIAO, HONG

Time:2017-12-29   Browse times:371

Professor, Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University

Tel: 086-25-83271043

Fax: 086-25-83271142

Cell phone: 13705185128

E-mail:lh_sophie@aliyun.com; hliao@cpu.edu.cn

  

Academic background

1983-1987    Bachelor of Science    Human and animal Physiology, Nanjing University

1987-1990    Master of Science       Neurochemistry, Nanjing University

2000-2004    Ph.D                          Neurobiology and Neuropharmacology, China PharmaceuticalUniversity

  

Academic Position

2005-now    Professor, Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, P.R. China

2002-2005   Research scientist, Neurobiology laboratory, Department of Clinical Research, Singapore General Hospital,

                   Singapor

1998-2002   Associate Professor, School of Medicine, Nanjing University, P.R. China

1992-1998   Lecturer,School of Medicine, Nanjing University,P.R. China

1990-1992   Assistant, School of Medicine, Nanjing University, P.R. China


Research Interests:

Our research focus on: (1)The role of glia on the neurodegenerative diseases, such as stroke, AD and brain trauma. (2) The effect of small molecules on neural stem cell proliferation and differentiation. (3) Drug screening and evaluation for natural compounds or synthesis compound in the neurodegenerative diseases.


Patent:

Name: Invention patent

Title: one kind of Traditional Chinese Medicine monomer which can promote neurite outgrowth from motor neuron.

Year: 2011.5

Country: China

Number for patent: 200910035486.


Honor and Award

The science and technology progress prize of the Ministry of Education (the second award): new drug screening core technology standardization platform construction and its scientific application.2014.1

  

Grants:


App ID

Title

FundingType & Grant Type

Your Role

First Year Funded

No. of Years

Total Amount

(RMB)

BK2006150

The effect of neuronal inhibitor molecules on neurite outgrowth   mediated by microglia

Natural Science Foundation of   Jiang Su Province support

CIA

2006

2.5

80,000

BZ2006050

The drug screening for neurodegeneration disease target on the HNK-1. Fund

International   Coorperation Projects of Jiang Su Provincesupport

CIA

2006

2.5

60.000

30670793

The effect of microglia on neuronal survival and neurite outgrowth   after CNS injury

National   Natural Science Foundation of China support

CIA

2007

3

270,000

2009ZX09302

The establishment of key technology and standarization platform   for new drug screening and scientific application

Mega-projects of Science Research   for the 11th Five-Year Plan support

participate

2008

3

1,000,000

BK2009296

The synthesis of novel anti-Alzheimer's disease agents and related   biological function.

Natural Science Foundation of Jiang Su Province support

participate

2009

4

100,000

81070967

The mechanism of NgR regulate glia involving neuroinflammation

National Natural Science Foundation of China support

CIA

2011

3

310,000

81271338

The role of neuroinflammation mediated by Nogo66/NgR signaling on   the Alzheimer's disease pathogenesis.

National Natural Science Foundation of China support

CIA

2013

4

700,000

20130096110011

  

The effect of NgR on microglia phagocytosis and degration Aβ in   the Alzheimer's disease.

The Specialized Research Fund for the Doctoral Program of Higher   Education of China support

CIA

2014

3

120,000

81572240

The effects of microglia on synaptic plasticity and neurogenesis   via CD200/CD200R signaling pathway during functional recovery after   post-stroke.

National Natural Science Foundation of China support

CIA

2015

4

684,000

BK20151441

The effects of microglia on neurogenesis via CD200/Cd200R   signaling pathway during functional recovery after post-stroke.

Natural Science Foundation of Jiang Su Province support

CIA

2015

3

100,000

81772063/H1504

The mechanism of p75NTR expressed on the astrocyte participating   cognition dysfunction via modulating synaptic plasticity.

National Natural Science Foundation of China support

CIA

2017

4

520,000


  

Published Paper: (From 2012-2017)

1. Liu Y, Li C, Wang J, Fang Y, Sun H, Tao X, , Zhou XF*Liao H*. Nafamostat Mesilate Improves Neurological Outcome and Axonal Regeneration after Stroke in Rats. Mol Neurobiol. 2017 Aug;54(6):4217-4231.

2. Chen MM, Qin J, Chen SJ, Yao LM, Zhang LY, Yin ZQ*, Liao H*. Quercetin promotes motor and sensory function recovery following sciatic nerve-crush injury in C57BL/6J mice. J Nutr Biochem. 2017 Apr 17;46:57-67. doi:10.1016/j.jnutbio.2017.04.006.

3. Liu H, Cheng Y, Yang J, Wang W, Fang S, Zhang W, Han B, Zhou Z, Yao H, Chao J*, Liao H*. BBC3 in macrophages promoted pulmonary fibrosis development through inducing autophagy during silicosis. Cell Death Dis. 2017 Mar 9; 8(3):e2657. doi: 10.1038/cddis.2017.78.

4. Bai YY, Ruan CS, Yang CR, Li JY, Kang ZL, Zhou L, Liu D, Zeng YQ, Wang TH, Tian CF, Liao H, Bobrovskaya L, Zhou XF*. ProBDNF Signaling Regulates Depression-Like Behaviors in Rodents under Chronic Stress. Neuropsychopharmacology. 2016 Jul 13. doi: 10.1038/npp.2016.100..

5. Liu H, Fang S, Wang W, Cheng Y, Zhang Y, Liao H, Yao H, Chao J. Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy. Part Fibre Toxicol. 2016 Oct 25;13(1):55. PubMed PMID: 27782836;

6. Liu H, Dai X, Cheng Y, Fang S, Zhang Y, Wang X, Zhang W, Liao H, Yao H, Chao J. MCPIP1 mediates silica-induced cell migration in human pulmonary fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2016 Jan 15;310(2):L121-32. doi: 10.1152/ajplung.00278.2015. PubMed PMID: 26608530.

7. Chang S, Ruan WC, Xu YZ, Wang YJ, Pang J, Zhang LY, Liao H*, Pang T*. The natural product 4,10-aromadendranediol induces neuritogenesis in neuronal cells in vitro through activation of the ERK pathway. Acta Pharmacol Sin. 2016 Nov 14. doi: 10.1038/aps.2016.115. [Epub ahead of print] PubMed PMID: 27840407

8. Li C, Wang J, Fang Y, Liu Y, Chen T, Sun H, Zhou XF*, Liao H*. Nafamostat Mesilate Improves Function Recovery after Stroke by Inhibiting Neuroinflammation in Rats. Brain Behav Immun. 2016,56:230-245

9. Fang Y, Yao L, Li C, Wang J, Wang J, Chen S, Zhou XF*, Liao H*. The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of Aβ plaques and tau phosphorylation in APP/PS1 transgenic mice. J Neuroinflammation. 2016 Mar 3; 13(1):56.

10. Fang Y, Yan J, Li C, Zhou X, Yao L, Pang T, Yan M, Zhang L, Mao L*, Liao H* The Nogo/Nogo Receptor (NgR) Signal Is Involved in Neuroinflammation through the Regulation of Microglial Inflammatory Activation. J Biol Chem. 2015 Nov 27; 290(48):28901-14.

11. Liu H, Dai X, Cheng Y, Fang S,Zhang Y, Wang X, Zhang W, Liao H, Yao H, Chao J#: MCPIP1 mediates silica-induced cell migration inhuman pulmonary fibroblasts. Am J Physiol-Lung C. 2015; DOI: 10.1152/ajplung.00278.2015(SCI, IF:4.08)

12. Wang J, Li C, Chen T, Fang Y, Shi X, Pang T, Zhang L*, Liao H*. Nafamostat mesilate protects against acute cerebral ischemia via blood-brain barrier protection. Neuropharmacology. 2016 Feb 6;105: 398-410.

13. Liu X, Fang S, Liu H, Wang X, Dai X, Yin Q, Yun T, Wang W, Zhang Y, Liao H, Zhang W, Yao H, Chao J#: Role of human pulmonary fibroblast-derived MCP-1 in cell activation and migration in experimental silicosis. Toxicol Appl Pharmacol 2015; 288:152-160 (SCI, IF:3.705)

14. Gao Y, Xu X, Chang S, Wang Y, Xu Y, Ran S, Huang Z, Li P, Li J, Zhang L, Saavedra JM, Liao H*, Pang T*. Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction. Toxicol Appl Pharmacol. 2015 Dec 1; 289(2):142-54.

15. Xu Y,Wang Y, Wang Y, He L, Jiang Z, Huang Z, Liao H, Li J, Saavedra JM, Zhang L, Pang T. Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKβ-dependent AMPK activation. Brain Behav Immun. 2015 Jul 16. pii: S0889-1591(15)00410-9.

16. Chen T, Wang J, Liu M, Zhang LY, Liao H*. Screening of natural compounds with neuronal differentiation promoting effects in a cell-based model. Chin J Nat Med. 2015; 13(8):602-8.

17. Chen MM, Yin ZQ, Zhang LY, Liao H*.Quercetin promotes neurite growth through enhancing intracellular cAMP level and GAP-43 expression.Chin J Nat Med. 2015;13(9):667-72.

18. Liu GX, Ni J, Mao L, Yan M, Pang T, Liao H*. Expression of Nogo receptor 1 in microglia during development and following traumatic brain injury. Brain Research 2015, 162741-51

19. Xu Y, Wang Y, Xu Y, Li J, Liao H*, Zhang L*, Pang T*. Development of a Novel Phosphorylated AMPK Protection Assay for High-Throughput Screening Using TR-FRET Assay. J Biomol Screen. 2015 ;20(7):906-12.

20. Ye Q, Li Q, Zhou Y, Xu L, Mao W, Gao Y, Li C, Xu Y, Xu Y, Liao H, Zhang L, Gao J, Li J, Pang T. Synthesis and Evaluation of 3-(furo[2,3-b]pyridin-3-yl)-4-(1H-indol-3-yl)-maleimides as Novel GSK-3β Inhibitors and Anti-Ischemic Agents. Chem Biol Drug Des. 2015 Feb 24. doi: 10.1111/cbdd.12546.

21. Ye Q, Mao W, Zhou Y, Xu L, Li Q, Gao Y, Wang J, Li C, Xu Y, Xu Y, Liao H, Zhang L, Gao J, Li J, Pang T. Synthesis and biological evaluation of 3-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-4-(indol-3-yl)-maleimides as potent, selective GSK-3β inhibitors and neuroprotective agents. Bioorg Med Chem. 2015;23(5):1179-88.

22. Ying-Ying Wang, Yuan-Xue Gao, Wei Gao, Yuan Xu, Ya-Zhou Xu, Yun-Jie Wang, Sai Chang, Li-Gang Yu, Lu-Yong Zhang, Hong Liao, Lian-Fang Yang, Tao Pang*, Wen-Wei Qiu*. Design, synthesis and biological evaluation of tricyclic diterpene derivatives as novel neuroprotective agents against ischemic brain injury. Eur. J. Med. Chem. 2015, 103: 396-408.

23. Xiaofeng Bao*, Xiaowei Cao, Xuemei Nie, Yuan Xu, Wanhua Guo, Baojing Zhou, Luyong Zhang, Hong Liao, Tao Pang. A new selective fluorescent chemical sensor for Fe3+ based on rhodamine B and a 1,4,7,10-tetraoxa-13-azacyclopentadecane conjugate and its imaging in living cells. Sens. Actuators B: Chem. 2015, 208: 54-66.

24. Chen T, Wang J, Li C, Zhang L, An L, Pang T, Shi X, Liao H*Nafamostat mesilate attenuates neuronal damage in a rat model of transient focal cerebral ischemia through thrombin inhibition. Scientific Reports2014 Jul 2;4:5531. doi:

25. Mei Liu, Jingjing Guo, Juan Wang, Luyong Zhang, Tao Pang*, Hong Liao*. Bilobalide induces neuronal differentiation of P19 embryonic carcinoma cells via activating Wnt/β-catenin pathway. Cell. Mol. Neurobiol. 2014, 34: 913-923.

26. Tao Pang, Li-xin Sun, Tao Wang, Zhen-zhou Jiang, Hong Liao*, Lu-yong Zhang*. Telmisartan protects central neurons against nutrient deprivation-induced apoptosis in vitro through activation of PPARγ and the Akt/GSK-3β pathway. Acta Pharmacol. Sin. 2014, 35(6): 727-737.

27. Liu FY, Wang YJ, Yan M, Zhang LY, Pang T*, Liao L*. Glimepiride attenuates Aβ production via suppressing BACE1 activity in cortical neurons. Neurosci. Lett.2013, 557: 90-94.

28. Chen, Yao; Sun, Jianfei; Peng, Sixun; Liao, Hong; Zhang, Yihua; Lehmann, JochenTacrine-flurbiprofen hybrids as multifunctional drug candidates for the treatment of Alzheimer's disease. Archiv der Pharmazie2013.346(12):865-71

29. Guo J, Wang J, Liang C, Yan J, Wang Y, Liu G, Jiang Z, Zhang L, Wang X, Wang Y, Zhou X, Liao H*. proNGF inhibits proliferation and oligodendrogenesis of postnatal hippocampal neural stem/progenitor cells through p75NTR in vitro. Stem Cell Res. 2013 ;11:874-87. 

30. Guo J, Wang J, Zhang Z, Yan J, Chen M, Pang T, Zhang L, Liao H*. proNGF inhibits neurogenesis and induces glial activation in adult mouse dentate gyrus. Neurochem Res. 2013;38:1695-703

31. Chen, Y ; Sun, JF ; Huang, ZJ ; Liao, H ; Peng, SX; Lehmann, J ; Zhang, YHNO-donating tacrine derivatives as potential butyrylcholinesterase inhibitors with vasorelaxation activityBioorganic & Medicinal Chemistry Letters2013.23(11): 3162-3165

32. Chen Y, Sun J, Huang Z, Liao H*, Peng S, Lehmann J, Zhang Y. Design, synthesis and evaluation of tacrine-flurbiprofen-nitrate trihybrids as novel anti-Alzheimer's disease agents. Bioorg Med Chem. 2013; 21:2462-70.

33. Sun J, Fang Y, Chen T, Guo J, Yan J, Song S, Zhang L, Liao H*WIN55, 212-2 promotes differentiation of oligodendrocyte precursor cells and improve remyelination through regulation of the phosphorylation level of the ERK 1/2 via cannabinoid receptor 1 after stroke-induced demyelination; Brain Res. 2013 23;1491:225-35.

34. Sun J, Fang YQ, Ren H, Chen T, Guo JJ, Yan J, Song S, Zhang LY, Liao H* WIN55,212-2 protects oligodendrocyte precursor cells in stroke penumbra following permanent focal cerebral ischemia in rats; Acta Pharmacol Sin. 2013 ;34(1):119-28.

35. Fan Y, Sun K, Mao L, Liao H, Wang HThe expression of PGC-1a in the mice brain after traumatic brain injury. Brain Injury. 2012; 26(10):1267–1272 [IF:1.36]

36. Chen Y, Sun J, Fang L, Liu M, Peng S, Liao H*Lehmann J, Zhang Y. Tacrine−Ferulic Acid−Nitric Oxide (NO) Donor Trihybrids as Potent,Multifunctional Acetyl- and Butyrylcholinesterase Inhibitors. J Med Chem. 2012, 55:4309− 4321 [IF:5.248]

37. Chen Y, Fang L, Peng S, Liao H, Lehmann J, Zhang YDiscovery of a novel acetylcholinesterase inhibitor by structure-based virtual screening techniques. Bioorganic & Medicinal Chemistry Letters, 2012,22:3181–3187

38. Guo J,Niu R, Huang W, Zhou M, Shi J, Zhang L,Liao H*Growth Factors from Tumor Microenvironment Possibly Promote the Proliferation of Glioblastom a-Derived Stem- like Cells in Vitro. Pathol Oncol Res .2012,18:1047–1057

39. Yan J, Zhou X, Guo J, Mao L, Wang Y, Sun J, Sun L, Zhang L, Zhou X, Liao H* Nogo-66 inhibits adhesion and migration of microglia via GTPase Rho pathway in vitro. J Neurochem.2012,120:721-731


新利18体育_18新利体育网页登录入口_18新利