新利18体育,18新利体育网页登录入口,18新利

Current Location:homepage  informations  doctordoctor

ZHANG, ZUNJIAN

Time:2017-12-29   Browse times:330

Professor of Pharmaceutical Analysis

Director of Institute of Pharmaceutical Sciences

Institute of Pharmaceutical Sciences, China pharmaceutical University

Phone: 86-25-83271454

Email: zzj@cpu.edu.cn

  

Research Summary

Professor ZHANG’s research focuses on the pharmaceutical analysis including drug quality evaluation and control in vitro & in vivo, pharmacokinetics and metabolism as well as analytical chemical toxicology. He recently published a paper entitled A pharmacometabonomic approach using predose serum metabolite profiles reveals differences in lipid metabolism in survival and non-survival rats treated with lipopolysaccharide(Metabolomics, 2016) which considers to understand inter-animal variability in toxic response to lipopolysaccharide. He has published more than 120 SCI papers.

  

Education

1994    Ph.D., Pharmaceutical Analysis, China Pharmaceutical University

1983    B.S., Pharmaceutical Analysis, Nanjing College of Pharmacy

  

Academic Experiences

2013-           Professor of Pharmaceutical Analysis, Institute of Pharmaceutical Science

2009-2013   Professor of Pharmaceutical Analysis, School of Pharmacy,

2004-2012   Professor of Pharmaceutical Analysis, Center for Instrumental Analysis

1997-2004   Associate Professor of Pharmaceutical Analysis, Center for Instrumental Analysis

1994-1997   Lecture of Pharmaceutical Analysis, Center for Instrumental Analysis

1986-1988   Clinical Pharmacist, Xuzhou Institute of Medical Science

1983-1986   Assistant Engineer, Tianjin Institute of Pharmaceutical Industry

  

Publications (2013-):

1. Guoqiang Liu, Yuan Tian, Geng Li, Lei Xu, Rui Song and Zunjian Zhang*: Metabolism of saikosaponin a in rats: Diverse oxidations on the aglycone moiety in liver and intestine besides hydrolysis of glycosidic bonds, Drug Metabolism and Disposition2013; 41:622–633

2. Yin Huang, Yuan Tian, Geng Li, Yuanyuan Li, Xinjuan Yin, Can Peng, Fengguo Xu*and Zunjian Zhang*: Discovery of safety biomarkers for realgar in rat urine using UFLC-IT-TOF/MS and 1H NMR based metabolomics, Analytical and Bioanalytical Chemistry,2013;405:4811–4822

3. Ji-xin Tian, Ming Wang, Lei Xu, Yuan Tian*, Rui Song, Fengguo Xu and Zunjian Zhang**: Metabolism of brucine: the important metabolic pathways of dihydroindole-type alkaloid for excretion in rats, Bioanalysis2014, 6(2):137-149

4. Mengru Wang,Yuanyuan Li, Yin Huang, Yuan Tian,Fengguo Xu*and Zunjian Zhang**: Chemomic and chemometric approach based on ultra-fast liquid chromatography with ion trap time-of-flight mass spectrometry to reveal the difference in the chemical composition between Da-Cheng-Qi decoction and its three constitutional herbal medicines, Journal of Separation Science, 2014 May;37(9-10):1148-54

5. Min Wang, Jinfeng Fu, Mengying Lv, Yuan Tian, Fengguo Xu, Rui Song*and Zunjian Zhang**: Effect of wine-processing and acute blood stasis on the serum pharmacochemistry of rhubarb: a possible explanation for processing mechanism, Journal of Separation Science2014, 37(18):2499-2503

6. Min Wang, Jinfeng Fu, Huimin Guo, Yuan Tian, Fengguo Xu, Rui Song*and Zunjian Zhang**: Discrimination of crude and processed rhubarb products using a chemometric approach based on ultra fast liquid chromatography with ion trap/time-of-flight mass spectrometry, Journal of Separation Science2015, 38(3): 395-401

7. Jing Wang, Hongyan Fan, Yong Wang, Xu Wang, Pei Zhang,Jiaqing Chen, Yuan Tian, Wei Zhang, Fengguo Xu*and Zunjian Zhang**: Metabolomic study of Chinese medicine Huang Qin Decoction as an effective treatment for irinotecan-induced gastrointestinal toxicity, RSC Advances, 2015, 5: 26420-26429

8. Hui Zhao, Xiao-dong She, Xia-xia Yu, Jin-feng Fu, Yun Chen, Yuan Tian and Zun-jian Zhang*:Quantification of iodiconazole by LC-MS/MS, a new topical transdermal cream, in dermatophytosis patients’ plasma, Bioanalysis2015,77:895-905

9. MengyingLv, Ping Xu, Yuan Tian, Jingyu Liang, Yiqiao Gao, Fengguo Xu, Zunjian Zhang* and Jianbo Sun**Medicinal uses, phytochemistry and pharmacology of the genus Dictamnus,Journal of Ethnopharmacology, 2015,171:247-263

10. Mengying Lv, Jianbo Sun, Min Wang, Wanqiu Huang, Hongyan Fan, Fengguo Xu* and Zunjian Zhang**: GC-MS based metabolomics study of stems and roots of Ephedra sinica, Journal of Pharmaceutical and Biomedical Analysis, 2015,114(3):49-52

11. Mengying Lv, Wanqiu Huang, Zhipeng Chen, Hulin Jiang, Jiaqing Chen, Yuan Tian, Zunjian Zhang* and Fengguo Xu**: Metabolomics techniques for nanotoxicity investigations, Bioanalysis, 2015,712:1527-1544

12. Mengying Lv, Jiaqing Chen, Jianbo Sun, Yiqiao Gao, Wanqiu Huang, Fengguo Xu* and Zunjian Zhang**: Metabolomics based on liquid chromatography with mass spectrometry reveals the chemical difference in the stems and roots derived from Ephedra sinica, Journal of separation science, 2015, 38(19): 3331-3336

13. Min Wang, Guangnan Hu, Yuan Tian, Zunjian Zhang* and Rui Song**: Influence of wine-processing on the pharmacokinetics of anthraquinone aglycones and glycosides from rhubarb in hyperlipidemic hamsters, RSC Advances, 2016, 6: 24871-24879

14. Ruiting Li, Peifang Liu, Peijia Liu, Yuan Tian, Yunfei Hua, Yiqiao Gao, Hua He, Jiaqing Chen, Zunjian Zhang* and Yin Huang**: A novel liquid chromatography tandem mass spectrometry method for simultaneous determination of branched-chain amino acids and branched-chain α-keto acids in human plasma, Amino Acids,2016,48(6):1523-1532

15. Die Dai, Yuan Tian, Huimin Guo, Pei Zhang, Yin Huang, Wei Zhang, Fengguo Xu* and Zunjian Zhang**: A pharmacometabonomic approach using predose serum metabolite profiles reveals differences in lipid metabolism in survival and non-survival rats treated with lipopolysaccharide, Metabolomics2016, DOI 10.1007/s 11306-015-0892-6

16. Huimin Guo, Jiaqin Chen, Yin Huang, Wei Zhang, Fengguo Xu* and Zunjian Zhang**:Pseudo-kinetics Approach for Time-Series Metabolomics Investigation: More Reliable and Sensitive Biomarkers Revealed in Vincristine-induced Paralytic Ileus Rat, RSC Advances, 2016, 6: 54471-54478, DOI: 10.1039/C6RA12641C

17. Zhang Pei, Chen Jiaqing, Wang Yong, Huang Yin, Tian Yuan, Zhang Zunjian* and Xu Fengguo**:Discovery of potential biomarkers with dose- and time-dependence in cisplatin-induced nephrotoxicity using metabolomics integrated with a principal component-based area calculation strategy, Chemical Research in Toxicology201629(5): 776-783

18. Rulin Wang, Lin Zhang, Yuan Tian* and Zunjian Zhang**: Simultaneous determination of levonorgestrel and two endogenous sex hormones in human plasma based on LC-MS/MS, Bioanalysis, 2016,811:1133-1144, doi: 10.4155/bio-2015-0036

19. Die Dai, Yiqiao Gao, Jiaqing Chen, Yin Huang, Zunjian Zhang* and Fengguo Xu**: Time-resolved metabolomics analysis of individual differences during the early stage of lipopolysaccharide-treated rats, Scientific Reports, 2016, 6:34136 doi: 10.1038/srep34136

20. Yiran Yao*, Pei Zhang*, Jing Wang, Jiaqing Chen, Yong Wang, Yin Huang, Zunjian Zhang* and Fengguo Xu**: Dissecting target toxic tissue and tissue specific responses of irinotecan in rats using metabolomics approach, Frontiers in Pharmacology, 2017, 8:122, doi:10.3389/fphar.2017.00122

21. Dongni Cui, Xu Wang, Jiaqing Cheng, Bo Lv, Pei Zhang, Wei Zhang, Zunjian Zhang* and Fengguo Xu**: Quantitative evaluation of the compatibility effects of Huangqin decoction on the treatment of irinotecan-induced gastrointestinal toxicity using untargeted metabolomics, Frontiers in Pharmacology,2017, 8:211, doi:10.3389/fphar.2017.00211

22. Cheng Jiaqing#, Zhang Pei#, Lv Mengyin,Guo Huimin,Huang Yin,Zhang Zunjian* and Xu Fengguo**: Influences of Normalization Method on Biomarker Discovery in Gas Chromatography-Mass Spectrometry-Based Untargeted Metabolomics: What Should be Considered? Analytical Chemistry, 2017,89(10):5342–5348, doi:10.1021/acs.analchem.6b05152

23. Huimin Guo#, Yu Jiao#, Xu Wang, Tao Lu, Zunjian Zhang* and Fengguo Xu**: Twins labeling-liquid chromatography/mass spectrometry based metabolomics for absolute quantification of tryptophan and its key metabolites, J Chromatography A, 1504201783-90doi: 10.1016/j.chroma.2017.05.008

24. Ruiqi Jiang#, Yu Jiao#, Pei Zhang, Yong Liu, Xu Wang, Yin Huang, Zunjian Zhang* and Fengguo Xu**: Twin Derivatization Strategy for High-Coverage Quantification of Free Fatty Acids by Liquid Chromatography–Tandem Mass Spectrometry, Analytical Chemistry, 201789(22):12223–12230,doi:10.1021/acs.analchem.7b03020


新利18体育_18新利体育网页登录入口_18新利